Icatibant in the Treatment of Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema
نویسندگان
چکیده
منابع مشابه
Treatment of angiotensin-converting enzyme inhibitor related angioedema with icatibant
Background The absolute risk of angiotensin-converting enzyme (ACE) inhibitor angioedema is 0.3% [1]. The mechanism is felt to be accumulation of bradykinin. The current treatment is discontinuation of ACE-I inhibitor, and intubation if necessary. Icatibant is a bradykinin receptor antagonist, useful in treating hereditary angioedema [2]. We present a patient from a Canadian center who had ACE-...
متن کاملIcatibant in the Treatment of Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema
We describe the case of a 75-year-old woman who presented with massive tongue and lip swelling secondary to angiotensin-converting enzyme inhibitor-induced angioedema. An awake fibre-optic intubation was performed because of impending airway obstruction. As there was no improvement in symptoms after 72 hours, the selective bradykinin B2 receptor antagonist icatibant (Firazyr) was administered a...
متن کاملAngiotensin-converting enzyme inhibitor-induced angioedema.
Angiotensin-converting enzyme (ACE) inhibitors frequently are prescribed for the management of cardiovascular disorders. In addition to their therapeutic potential, ACE inhibitors are associated with numerous adverse effects, some of which may be lethal. Angioedema is an uncommon but serious acute event that may affect any individual taking an ACE inhibitor. This review outlines the advances in...
متن کاملRandomized Trial of Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Upper Airway Angioedema.
BACKGROUND Upper airway angioedema is a rare, unpredictable, and at times life-threatening adverse effect of angiotensin-converting enzyme inhibitors (ACE-Is) with no existing effective pharmacologic treatment. Icatibant is a bradykinin B2 receptor antagonist that may be beneficial in patients with ACE-I-induced angioedema. OBJECTIVE We aimed to evaluate the efficacy of icatibant in subjects ...
متن کاملManagement of angiotensin-converting enzyme inhibitor-induced angioedema.
OBJECTIVES/HYPOTHESIS To develop and validate a clinical algorithm for management of patients with angiotensin-converting enzyme inhibitor-induced angioedema (AIIA). STUDY DESIGN Prospective cohort observational study. METHODS Over 1 year, 40 patients with AIIA were evaluated by otolaryngology, underwent laryngoscopy, and were followed until disease resolution. The need for airway intervent...
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ژورنال
عنوان ژورنال: Case Reports in Critical Care
سال: 2014
ISSN: 2090-6420,2090-6439
DOI: 10.1155/2014/864815